2. Signaling Pathways
  3. Immunology/Inflammation
  4. Salt-inducible Kinase (SIK)

Salt-inducible Kinase (SIK)

Salt-inducible Kinase (SIK)

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Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and functions mainly involve in regulating energy response-related physiological processes, such as gluconeogenesis and lipid metabolism. The SIK family comprises three isoforms, namely, SIK1, SIK2, and SIK3, all of which may act as metabolic transmitters. SIKs have shown self-phosphorylation, and play an important role in regulating adrenocortical function under the stimulation of high salt or adreno-cortico-tropic-hormone (ACTH).

All three SIK family kinases are expressed broadly. SIK1 mRNA expression is regulated by multiple stimuli, including high dietary salt intake, ACTH signaling, glucagon signaling, excitable cell depolarization, and circadian rhythms. In contrast, SIK2 and SIK3 expression is constitutive in tissues in which these kinases are expressed. In humans, SIK2 and SIK3 are expressed ubiquitously, with highest SIK2 levels in adipose tissue and highest SIK3 expression in brain. In addition, these SIK family members are dysregulated in various cancers, including ovarian, breast, prostate, and lung cancers, indicating that SIKs may execute crucial roles in tumor occurrence or progression.

Salt-inducible Kinase (SIK) Isoform Specific Products:

Salt-inducible Kinase (SIK) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163743
    SIC-19
    		Inhibitor ≥98.0%
    SIC-19 is a SIK2 inhibitor and promotes SIK2 protein degradation via the ubiquitination pathway. SIC-19 inhibits cancer cell growth and sensitizes cells to PARP inhibitors (Such as Olaparib (HY-10162)), as well as in ovarian cancer organoids and xenograft models.
    SIC-19
  • HY-RS12918
    Sik3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sik3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sik3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sik3 Mouse Pre-designed siRNA Set A
    Sik3 Mouse Pre-designed siRNA Set A
  • HY-RS12915
    Sik2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sik2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sik2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sik2 Mouse Pre-designed siRNA Set A
    Sik2 Mouse Pre-designed siRNA Set A
  • HY-149365
    SIKs-IN-1
    		Inhibitor
    SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model.
    SIKs-IN-1
  • HY-RS12912
    Sik1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sik1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sik1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sik1 Mouse Pre-designed siRNA Set A
    Sik1 Mouse Pre-designed siRNA Set A
  • HY-RS12914
    SIK2 Human Pre-designed siRNA Set A
    		Inhibitor

    SIK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIK2 Human Pre-designed siRNA Set A
    SIK2 Human Pre-designed siRNA Set A
  • HY-RS12913
    Sik1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sik1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sik1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sik1 Rat Pre-designed siRNA Set A
    Sik1 Rat Pre-designed siRNA Set A
  • HY-P1576
    AMARA peptide
    AMARA peptide is a substrate for SIK and AMPK.
    AMARA peptide
  • HY-149075
    MR22
    		Inhibitor
    MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells.
    MR22
  • HY-N1570R
    Pterosin B (Standard)
    		Inhibitor
    Pterosin B (Standard) is the analytical standard of Pterosin B (HY-N1570). This product is intended for research and analytical applications. Pterosin B is an indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes.
    Pterosin B (Standard)
  • HY-171591
    SIK2-IN-4
    		Inhibitor
    SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC50: 0.11 µM), IL-12/23 p40 (IC50: 0.25 µM), and IL-23 (IC50: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases.
    SIK2-IN-4
Salt-inducible Kinase (SIK) Isoform Comparison

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